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Upa Pada

Upa Pada as narrated in Parasara Hora, the Bible of Astrology. The data of Parasara could be attributed to the roughly Mahabharata era.

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One cannot study a horoscope by only looking at the natal chart. Padas as described in BPHS will further change the planetary effects. Essentially, the Rishi says Raja Yogas are best analysed through Pada Chart.

If one wants to do deeper research, Upa pada will be more effective.

The auspiciousness of Upa Pada will essentially determine the benevolence that the native enjoys from wife, children, family life, etc.

Natal ascendant will be the basis for calculating the Upa Pada and is also called Gauna Pada. If Upa Pada is with a benefic or as packed by a benefic, one will gain happiness through children and work. If the Upa Pada is conjoined, aspected and afflicted by a malefic, then the native may out gone married life.

It is generally understood that the Pada for the 12th or the 2nd from the Lagna is called Upa Pada. 12th from the ascendant for an odd sign and 2nd from the ascendant in for even sign.

Examples : Take an even sign, Scorpio ascendant. The second house Lord is situated 8 signs away from Sagittarius. Hence we should count 8 signs from Cancer where Jupiter is placed.

Results of 2nd from Upa Pada

If the 2nd from Upa Pada is associated with benefic, then the native will beblessed with wife and son. In case if the 2nd from Upa Pada is occupied or aspected by a malefic, there will be loss of wife. Loss of wife is expected is a debilated planet week in Shadbala is occupying 2nd from Upa Pada. Taurus as Upa Pada may give many wifes.

If the 2nd from Upa Pada is associated with a benefic, the wife will be affluent, fortunate and virtuous.

In case Saturn and Rahu conjunction is there in 2nd house, the native may lose his wife. Some way if Venus and Ketu are in the 2nd house, wife might suffer from disorder of blood, etc.

Mercury with Rahu or Ketu in 2nd house will cause disasters. Good may happen if a benefic is conjunct or aspects.

Results or effects from natal ascendant, Lagna Pada and the 7th from Upa Pada.

If there is conjunction of Saturn, Moon and Mercury in the 9th , there won't be sons for the native. The son will be strong, valourous and successful if there is a conjunction of Sun, Jupiter and Rahu in the 9th.

If malefic Saturn and Rahu are in the 9th, predict no sons.

In case if Leo happens to be Upa Pada and is aspected by the Moon, predict limited number of children. Similarly, Virgo will have many daughters.

Other matters from Lagna Pada

Native will be evil if 6th from Lagna Pada is occupied by a malefic and is bereft of the good effects of a benefic.

If Rahu is in the 7th or 12th from Lagna Pada or aspects, the native will have spiritual qualities and also be very fortunate.

If Mercury, Jupiter or Moon in Lana Pada, the native will be Lord, knower of all things and a poet respectively.

Generally, if a benefic occupies the 2nd from Lagna, then the native will be blessed with all kinds of wealth and intelligence.

In this article, an attempt has been made to highlight the work of Rishi Parasara in the area of concept of Upa Pada and its significance.

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Platelet-rich plasma - PRP Therapy

Platelet-rich plasma PRP is one of the broader regenerative medicines, but shortly after its clinical application, it is not currently
the standard treatment for various orthopedic diseases. At the stage of accumulating clinical data, we ask
patients to fully understand the characteristics of this treatment method and the condition of their own disease before considering it as a treatment option.

In this "Academic Commentary Corner", we will explain the latest findings in academic societies and treatises in an easy-to-understand manner so as to help understanding and examination.


Creating PRP


PRP is made from your own blood. As you may have seen in biology textbooks, blood separates into layers as shown in the figure below when left in a test tube or centrifuged. Blood cells other than red blood cells, that is, white blood cells and platelets, gather in the central part with a volume of less than 1% and are called a buffy coat.

In reality, many platelets are suspended in the lower layer of plasma, which accounts for 55%, and this range is called Platelet Rich Plasma (PRP). PRP therapy involves extracting this part (on the right side of the figure below, surrounded by red ) with a special prp tubes and injecting it into the affected area as a treatment.

Growth factors and anti-inflammatory cytokines contained in platelets

Platelets have the role of quickly clotting blood from each other to form a clot and damming the priesthood in order to prevent blood leakage from blood vessels when bleeding occurs. However, since the publication of the research in 1970, it has become clear that it actually releases various substances to other cells and also plays a role in directing wound healing. This released substance is called "humoral factor" or "growth factor".

A "humoral factor" or "growth factor" is a small-sized protein molecule, PDGF, TGF-β, VEGF, FGF, IGF (insulin-like growth factor), HGF (hepatocyte growth factor), BMP (bone formation). Protein) etc. (* 3).

Different types of PRP

There are several types of PRP in a bite. The composition of PRP depends on the kits and test tubes used to make it. Furthermore, since self-peripheral venous blood naturally differs from person to person depending on the individual who collects blood, it is not possible to simply compare the results of the same treatment as with drugs. The major differences are shown in the table below. At this hospital, two treatment methods, LR-PRP and PFC-FD, shown in the table below are available.

Mechanism of action of PRP

Platelets release many humoral and growth factors when healing wounds (called "wound healing"). Its components include PDGF (platelet-derived growth factor), TGF-β (β-type mutant growth factor), VEGF (vascular endothelial growth factor), FGF (fibroblast growth factor), IGF (insulin-like growth factor), and HGF ( Hepatocyte growth factor), BMP (bone-forming protein), etc. are known (* 3). In basic experiments using cell culture, PRP promotes chondrocyte differentiation, proliferation, and cartilage substrate production by the action of these protein molecules. In addition, it was found that it has the effect of increasing hyaluronic acid present in the joint cavity and lubricin released from articular cartilage surface cells and synovial cells, and suppressing the expression of substrate degrading enzymes (MMP: matrix degrading enzymes, etc.). (* 5).
However, it is not clear how the effect of improving clinical symptoms such as joint pain is obtained. However, it is speculated that the above-mentioned humoral factors and growth factors released from platelets contribute to the tissue remodeling and anti-inflammatory effects during wound healing.

As introduced earlier, there are various extraction and purification methods for PRP, and the number of platelets per mL, the presence or absence of white blood cells contained, and the number of white blood cells contained differ from sample to sample. Above all, the presence or absence of leukocytes may greatly affect the action.

Leukocyte-rich PRP, which is rich in leukocytes, has a high pro-inflammatory effect, has a catabolism to the injection site (decomposes tissue structure), and contains a large amount of substrate-degrading enzymes (MMP: matrix-degrading enzymes, etc.). Is suggested (* 3). On the other hand, leukocyte-poor PRP, which does not contain a lot of white blood cells, has a high anti-inflammatory effect, has an anabolic effect on the injection site (assembles tissue structure), and suppresses substrate degrading enzymes (MMP: matrix degrading enzymes, etc.). , Is inferred.

Autologus protein solution (APS) is intended to increase the concentration of anti-inflammatory cytokines by further dehydrating LR-PRP, and its use is increasing in Japan as well. In fact, a study comparing the levels of cytokines contained in PRP has reported that IL1-ra, one of the anti-inflammatory cytokines, is abundant in APS.